反应详情

0.82 g (1.84 mmol) of 7-chloro-3-(5-diisopropylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one was dissolved in 20 ml of hot ethanol and treated at 0° with 0.55 ml (2.02 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 30 minutes the solution was totally concentrated. The product was recrystallized from hot acetonitrile/ethyl acetate. There was obtained 0.74 g (83%) of 7-chloro-3-(5-diisopropylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 206°-210° (dec.).

1. concentrationwas totally concentrated
2. customThe product was recrystallized from hot acetonitrile/ethyl acetate