Hydrazine hydrate (1:1) → HCID 77340521, compound

Participants

Reaction Steps

10 ml of hydrazine hydrate were added to a suspension of 6.0 g (19.8 mmol) of ethyl (S)-8-oxo-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepine-1-carboxylate in 50 ml of ethanol and the mixture was heated at reflux for 3 hours. After cooling to 0° the crystals obtained were filtered off and there were obtained 5.6 g (98%) of S)-8-oxo-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno-[3,2-e][1,4]diazepine-1-carboxylic acid hydrazide as colourless needles of m.p. 260°-263°.

Provenance & Evidence