Hydrazine hydrate (1:1) → HCID 77340521, compound

HRID 1378254Notes

Reaction equation

HRID 1378254 reaction equation
O.[NH2:2][NH2:3].[O:4]=[C:5]1[N:11]2[CH2:12][CH2:13][C@H:10]2[C:9]2=[C:14]([C:17]([O:19]CC)=O)[N:15]=[CH:16][N:8]2[C:7]2[CH:22]=[CH:23][S:24][C:6]1=2>C(O)C>[O:4]=[C:5]1[N:11]2[CH2:12][CH2:13][CH:10]2[C:9]2=[C:14]([C:17]([NH:2][NH2:3])=[O:19])[N:15]=[CH:16][N:8]2[C:7]2[CH:22]=[CH:23][S:24][C:6]1=2

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 53981632HCID 53981632, compound

Product 1

HCID 77340521HCID 77340521, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10 ml of hydrazine hydrate were added to a suspension of 6.0 g (19.8 mmol) of ethyl (S)-8-oxo-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepine-1-carboxylate in 50 ml of ethanol and the mixture was heated at reflux for 3 hours. After cooling to 0° the crystals obtained were filtered off and there were obtained 5.6 g (98%) of S)-8-oxo-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno-[3,2-e][1,4]diazepine-1-carboxylic acid hydrazide as colourless needles of m.p. 260°-263°.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 3 hours
  3. temperatureAfter cooling to 0° the crystals
  4. customobtained
  5. filtrationwere filtered off

Sources & evidence

ORD record
ord-328db6b80d354417972f4c10c6e216f8
Source dataset
uspto-grants-1997_09
Patent number
US05665718

Reaction notes

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