1-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine → 1-(2-Phenoxypropyl)-4-benzylpiperazine

HRID 1378327Notes

Reaction equation

HRID 1378327 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]([C:10]([N:12]3[CH2:17][CH2:16][N:15]([CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH2:14][CH2:13]3)=O)[CH2:7][C:6]=2[CH:25]=1.Cl.O(C(C)C(N1CCN(CC2C=CC=CC=2)CC1)=O)C1C=CC=CC=1>>[O:9]([CH:8]([CH3:7])[CH2:10][N:12]1[CH2:13][CH2:14][N:15]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:16][CH2:17]1)[C:5]1[CH:4]=[CH:3][CH:2]=[CH:25][CH:6]=1

Participants

3

Reactant 2

HCID 214722611-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazineHCID 214722661-(2-Phenoxypropionyl)-4-benzylpiperazine hydrochloride

Product 1

HCID 97967301-(2-Phenoxypropyl)-4-benzylpiperazine

Procedure

By carrying out the preparation as in Example 1, but replacing 1-[(5-fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine with the 1-(2-phenoxypropionyl)-4-benzylpiperazine hydrochloride obtained in Example 7, the title product is obtained.

Workup

  1. customthe preparation as in Example 1

Sources & evidence

ORD record
ord-c982341893cc4ae0bcee43d8ed95726f
Source dataset
uspto-grants-1997_09
Patent number
US05668138

Reaction notes

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