Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Carbamic acid, [[(3R,4R)-4-(trifluoromethyl)-3-pyrrolidinyl]methyl]-, 1,1-dimethylethyl ester, rel- | HCID 57429455 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 70207318 | HCID 70207318 | 88.6% |
Reaction Steps
In 1 ml of dichloromethane, is dissolved 202 mg (0.754 mmol) of trans-3-(tert-butoxycarbonylaminomethyl)-4-trifluoromethylpyrrolidine. To the above solution, is added 1 ml of trifluoroacetic acid on cooling with ice, and the mixture is stirred at 0° C. for 1 hour. To the reaction mixture, is added 0.19 ml of conc-hydrochloride, and the mixture was concentrated under reduced pressure to give 161 mg of the objective substance as a slightly yellow powder (yield 88.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05668147 |
|---|
| Source dataset | uspto-grants-1997_09 |
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| ORD ID | ord-309054bc17104c7da262620b31d23a7b |
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| Source note | uspto-grants-1997_09 |
|---|
