Hydrochloric Acid → HCID 70207318, compound

HRID 1378389Notes

Reaction equation

HRID 1378389 reaction equation
C(OC([NH:8][CH2:9][C@H:10]1[C@H:14]([C:15]([F:18])([F:17])[F:16])[CH2:13][NH:12][CH2:11]1)=O)(C)(C)C.FC(F)(F)C(O)=O.Cl>ClCCl>[NH2:8][CH2:9][C@H:10]1[C@H:14]([C:15]([F:18])([F:16])[F:17])[CH2:13][NH:12][CH2:11]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 57429455Carbamic acid, [[(3R,4R)-4-(trifluoromethyl)-3-pyrrolidinyl]methyl]-, 1,1-dimethylethyl ester, rel-

Product 1

HCID 70207318HCID 70207318, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

In 1 ml of dichloromethane, is dissolved 202 mg (0.754 mmol) of trans-3-(tert-butoxycarbonylaminomethyl)-4-trifluoromethylpyrrolidine. To the above solution, is added 1 ml of trifluoroacetic acid on cooling with ice, and the mixture is stirred at 0° C. for 1 hour. To the reaction mixture, is added 0.19 ml of conc-hydrochloride, and the mixture was concentrated under reduced pressure to give 161 mg of the objective substance as a slightly yellow powder (yield 88.6%).

Workup

  1. temperatureon cooling with ice
  2. concentrationthe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-309054bc17104c7da262620b31d23a7b
Source dataset
uspto-grants-1997_09
Patent number
US05668147

Reaction notes

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