反应详情

A tablespoonful of Raney nickel catalyst in water was washed first with 95% EtOH and then with EtOAc; it was added to a solution of 2-chloro-3,5-dinitropyridine (4.00 g, 0.0196 mol) in EtOAc (150 ml) and the mixture was hydrogenated at an initial hydrogen pressure of 47.5 p.s.i. for 3 hours. The mixture was filtered through celite and the filtrate was concentrated. The residue was crystallized from CH2Cl2 -pentane to give 1.83 g of the titled product.

1. washA tablespoonful of Raney nickel catalyst in water was washed first with 95% EtOH
2. filtrationThe mixture was filtered through celite
3. concentrationthe filtrate was concentrated
4. customThe residue was crystallized from CH2Cl2 -pentane