Diphenyl N-Cyanocarbonimidate → N'-Cyano-N-(2-dimethylamino-3-pyridyl)-O-phenylisourea

HRID 1378440Notes

Reaction equation

HRID 1378440 reaction equation
[NH2:1][C:2]1[C:3]([N:8]([CH3:10])[CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[CH:11]1[CH:16]=[CH:15][C:14]([O:17][C:18](OC2C=CC=CC=2)=[N:19][C:20]#[N:21])=[CH:13][CH:12]=1>COCCOC>[C:20]([N:19]=[C:18]([O:17][C:14]1[CH:15]=[CH:16][CH:11]=[CH:12][CH:13]=1)[NH:1][C:2]1[C:3]([N:8]([CH3:10])[CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1)#[N:21]

Participants

4

Reactant 2

HCID 688090Diphenyl N-CyanocarbonimidateHCID 15656134N2,N2-Dimethyl-2,3-pyridinediamine

Product 1

HCID 178483039N'-Cyano-N-(2-dimethylamino-3-pyridyl)-O-phenylisourea

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A stirred mixture of the product from Step 2 (0.738 g, 0.00538 mol), diphenylcyanocarbonimidate (1.28 g, 0.00538 mol) and ethylene glycol dimethyl ether (40 ml) was kept, under nitrogen, at ambient temperature (25° C.) for 7 hours. The mixture was concentrated and the residue was used in the next step without further purification.

Workup

  1. customwas kept, under nitrogen, at ambient temperature
  2. custom(25° C.)
  3. customfor 7 hours
  4. concentrationThe mixture was concentrated
  5. customthe residue was used in the next step without further purification

Sources & evidence

ORD record
ord-afaa4dd71b454a73b6d98bd61ac9c840
Source dataset
uspto-grants-1997_09
Patent number
US05668157

Reaction notes

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