反应详情

To a mixture of 7.55 g (0.05 mol) of 4-amino-phenylacetic acid and 15.15 g (0.15 mol) of triethyl-amine in 25 mL of ethyl cellosolve was added 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride (Arzneimittel Forsch., 1964;14:1301). The mixture was stirred at room temperature for 3 hours, concentrated in vacuo, and water was added to the residue. The mixture was acidified with HCl and filtered to give 9.9 g of the title compound, mp 173°-175° C.

1. concentrationconcentrated in vacuo, and water
2. additionwas added to the residue
3. filtrationfiltered