Methane → HCID 8966203, compound

HRID 1378552Notes

Reaction equation

HRID 1378552 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[CH3:16][C:17]([C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[Cl:26])=O.O.C1(C)C(S(O)(=O)=O)=CC=CC=1.C>C(O)C>[Cl:26][C:20]1[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:19]=1[C:17]1[CH:16]=[C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Participants

6

Reactant 4

HCID 297MethaneHCID 75587Ethanone, 1-(2,5-dichlorophenyl)-HCID 760802-AminobenzophenoneHCID 124969952-Methylbenzenesulfonic acid hydrate

Product 1

HCID 8966203HCID 8966203, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Aminobenzophenone (33 g) and 2,5-dichloroacetophenone (32 g) were placed in a flask together with 2.5 g of toluenesulfonic acid monohydrate. The mixture was heated and stirred at 160°-170° C. for 24 hours. The resulting mixture was diluted with ethanol (300 ml). The crystals was filtered to give 63 g crude product, which was treated with charcoal and recrystallized first from ethanol, followed by recrystallization from hexane and ethyl acetate to give monomer as white crystals (65%).

Workup

  1. temperatureThe mixture was heated
  2. filtrationThe crystals was filtered
  3. customto give 63 g crude product, which
  4. customrecrystallized first from ethanol
  5. customfollowed by recrystallization from hexane and ethyl acetate

Sources & evidence

ORD record
ord-dd17c0f4f1114ed68c824fc9cdd09a8f
Source dataset
uspto-grants-1997_09
Patent number
US05668245

Reaction notes

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