反应详情

Sodium acetate (517 mg) and hydroxylamine hydrochloride (219 mg) were successively added to a methanol-methylene chloride solution (10-10 ml) of 1.00 g of the (S)-N-{3-[3-fluoro-4-(4-oxo-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (Compound No. 7) synthesized in Example 3, and the mixture was stirred at room temperature for 2 days. The solvent was evaporated and the residue was dissolved in methanol, followed by addition of a silica gel (8 g). Methanol was evaporated and the residue was purified by silica gel column chromatography (solvent: chloroform/methanol=50/1-25/1) to afford the title compound (852 mg) in a yield of 82%.

1. custom7) synthesized in Example 3
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in methanol
4. additionfollowed by addition of a silica gel (8 g)
5. customMethanol was evaporated
6. customthe residue was purified by silica gel column chromatography (solvent: chloroform/methanol=50/1-25/1)