Acetyl chloride → HCID 178497913, compound

HRID 1378699Notes

Reaction equation

HRID 1378699 reaction equation
[C:1](Cl)(=O)C.[OH:5][C:6]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[C:8]([CH3:15])[N:7]=1>CO>[CH3:1][O:13][C:12]([C:11]1[C:6]([OH:5])=[N:7][C:8]([CH3:15])=[CH:9][CH:10]=1)=[O:14]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178425908HCID 178425908, compound

Product 1

HCID 178497913HCID 178497913, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetyl chloride (50 ml) was added cautiously to a stirred suspension of 2-hydroxy-6-methylpyridine-3-carboxylic acid (14.3 g, 93.44 mmol) in dry methanol (500 ml) and the resulting solution was heated to reflux. After 16 h the solution was evaporated in vacuo to give the title compound (15.62 g, 100%) as a solid: 1H NMR (DMSO) shows the methyl singlet at δ 3.71.

Workup

  1. temperaturethe resulting solution was heated to reflux
  2. customAfter 16 h the solution was evaporated in vacuo

Sources & evidence

ORD record
ord-9892c3ce260e405e984e4a33138acbd3
Source dataset
uspto-grants-1997_09
Patent number
US05668289

Reaction notes

Loading…