Acetyl chloride → HCID 178497913, compound

Participants

Reaction Steps

Acetyl chloride (50 ml) was added cautiously to a stirred suspension of 2-hydroxy-6-methylpyridine-3-carboxylic acid (14.3 g, 93.44 mmol) in dry methanol (500 ml) and the resulting solution was heated to reflux. After 16 h the solution was evaporated in vacuo to give the title compound (15.62 g, 100%) as a solid: 1H NMR (DMSO) shows the methyl singlet at δ 3.71.

Provenance & Evidence