2,4-Difluoronitrobenzene → Glycine, N-(5-fluoro-2-nitrophenyl)-, ethyl ester

HRID 1378729Notes

Reaction equation

HRID 1378729 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Cl.[CH2:13]([O:15][C:16](=[O:19])[CH2:17][NH2:18])[CH3:14].C(N(C(C)C)CC)(C)C>C(#N)C>[CH2:13]([O:15][C:16](=[O:19])[CH2:17][NH:18][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10])[CH3:14]

Participants

5

Reactant 3

HCID 679672,4-DifluoronitrobenzeneHCID 81531DiisopropylethylamineHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 10331949Glycine, N-(5-fluoro-2-nitrophenyl)-, ethyl ester

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a mixture of 2,4-difluoronitrobenzene (VII, 19.20 g), glycine ethyl ester hydrochloride (XII, 16.52 g), and acetonitrile (50 ml) is added diisopropylethylamine (42 ml). A mild exotherm ensues. The reaction is stirred (without cooling) for two hours. The acetonitrile is removed under reduced pressure and the residue is partitioned between dichloromethane and water. The organic layers are dried over sodium sulfate and concentrated to give the produce as a solid (single spot by TLC), mp 194°-195°; NMR (CDCl3) 1.33, 4.05, 4.30, 6.35, 6.45, 8.26 and 8.56 δ.

Workup

  1. temperature(without cooling) for two hours
  2. customThe acetonitrile is removed under reduced pressure
  3. customthe residue is partitioned between dichloromethane and water
  4. dry with materialThe organic layers are dried over sodium sulfate
  5. concentrationconcentrated
  6. customto give the
  7. customproduce as a solid (single spot by TLC), mp 194°-195°

Sources & evidence

ORD record
ord-d6d30e1621d34aa4ae6c798298cbb2c7
Source dataset
uspto-grants-1997_09
Patent number
US05668282

Reaction notes

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