HRID1378792

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(=O)Nc1ccc(SSc2ccc(NC(C)=O)cc2C(=O)NC(CC(C)C)C(=O)OC(C)(C)C)c(C(=O)NC(CC(C)C)C(=O)OC(C)(C)C)c1

HCID54282518

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1ccc(SSc2ccc(NC(C)=O)cc2C(=O)NC(CC(C)C)C(=O)O)c(C(=O)NC(CC(C)C)C(=O)O)c1

HCID6917073

未命名化合物

收率 77.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

This compound was prepared according to the procedure described in Example 50 using [S-(R*,R*)] 2-{5-acetylamino-2-[4-acetylamino-2-(1-tert-butoxycarbonyl-3-methyl-butylcarbamoyl)-phenyldisulfanyl]-benzoylamino}-4-methyl-pentanoic acid tert-butyl ester (0.2 g, 0.2 mmol) from Example 44, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The crude product was recrystallized from dimethylformamide/water to afford 0.1 g of the title compound, mp 241°-242° C.

WORKUP

后处理

customThis compound was prepared
customThe crude product was recrystallized from dimethylformamide/water

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ed8e054f5af4563a1036a3a9787fabb
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05668291
来源说明: uspto-grants-1997_09

反应 SMILES

C([O:5][C:6](=[O:52])[CH:7]([NH:12][C:13](=[O:51])[C:14]1[CH:19]=[C:18]([NH:20][C:21](=[O:23])[CH3:22])[CH:17]=[CH:16][C:15]=1[S:24][S:25][C:26]1[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:35])[CH3:34])=[CH:28][C:27]=1[C:36](=[O:50])[NH:37][CH:38]([C:43]([O:45]C(C)(C)C)=[O:44])[CH2:39][CH:40]([CH3:42])[CH3:41])[CH2:8][CH:9]([CH3:11])[CH3:10])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[C:21]([NH:20][C:18]1[CH:17]=[CH:16][C:15]([S:24][S:25][C:26]2[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:35])[CH3:34])=[CH:28][C:27]=2[C:36](=[O:50])[NH:37][CH:38]([C:43]([OH:45])=[O:44])[CH2:39][CH:40]([CH3:41])[CH3:42])=[C:14]([CH:19]=1)[C:13]([NH:12][CH:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6]([OH:52])=[O:5])=[O:51])(=[O:23])[CH3:22]