HRID1378793

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CCNc1ccc(SSc2ccc(NCC)cc2C(=O)NC(C(=O)OC(C)(C)C)C(C)CC)c(C(=O)NC(C(=O)OC(C)(C)C)C(C)CC)c1

HCID76501948

未命名化合物

PRODUCTS

生成物

结构：CCNc1ccc(SSc2ccc(NCC)cc2C(=O)N[C@H](C(=O)O)[C@@H](C)CC)c(C(=O)N[C@H](C(=O)O)[C@@H](C)CC)c1

HCID54082498

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

This compound was prepared according to the procedure described in Example 50 using [S-(R*,R*)] 2-{5-ethylamino-2-[4-ethylamino-2-(1-tert-butoxy carbonyl-2-methyl-butylcarbamoyl)-phenyldisulfanyl]benzoylamino}-3-methyl-pentanoic acid tert-butyl ester (0.8 g, 1.1 mmol) from Example 45, 10 mL dichloromethane, and 10 mL trifluoroacetic acid. The product was washed with hexane/ether to afford 0.6 of the title compound, mp 97°-100° C.

WORKUP

后处理

customThis compound was prepared
washThe product was washed with hexane/ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2d1479d5987b4999ba9ef27abaf69886
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05668291
来源说明: uspto-grants-1997_09

反应 SMILES

C([O:5][C:6](=[O:50])[CH:7]([NH:12][C:13](=[O:49])[C:14]1[CH:19]=[C:18]([NH:20][CH2:21][CH3:22])[CH:17]=[CH:16][C:15]=1[S:23][S:24][C:25]1[CH:30]=[CH:29][C:28]([NH:31][CH2:32][CH3:33])=[CH:27][C:26]=1[C:34](=[O:48])[NH:35][CH:36]([C:41]([O:43]C(C)(C)C)=[O:42])[CH:37]([CH3:40])[CH2:38][CH3:39])[CH:8]([CH3:11])[CH2:9][CH3:10])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:21]([NH:20][C:18]1[CH:17]=[CH:16][C:15]([S:23][S:24][C:25]2[CH:30]=[CH:29][C:28]([NH:31][CH2:32][CH3:33])=[CH:27][C:26]=2[C:34]([NH:35][C@H:36]([C:41]([OH:43])=[O:42])[C@H:37]([CH2:38][CH3:39])[CH3:40])=[O:48])=[C:14]([C:13]([NH:12][C@H:7]([C:6]([OH:50])=[O:5])[C@H:8]([CH2:9][CH3:10])[CH3:11])=[O:49])[CH:19]=1)[CH3:22]