Methyl iodide → HCID 178503998, compound

HRID 1378909Notes

Reaction equation

HRID 1378909 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH2:11])=[S:10])[CH:5]=[CH:6][CH:7]=1.[CH3:12][I:13]>C(O)C>[IH:13].[CH3:12][S:10][C:9](=[NH:11])[NH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 2734799(3-Fluorophenyl)thiourea

Product 1

HCID 178503998HCID 178503998, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-fluorophenylthiourea (20.0 g, 166.7 mmol) and methyl iodide (24.8 g, 175.0 mmol) in 300 ml of ethanol is stirred at RT for 2 days. It is then heated to reflux for 30 min., cooled and stripped of solvent to give S-methyl-3-fluorophenylisothiourea hydroiodide, an orange solid.

Workup

  1. temperatureIt is then heated
  2. temperatureto reflux for 30 min.
  3. temperaturecooled

Sources & evidence

ORD record
ord-950b836463ff495eabd5a1f448773a22
Source dataset
uspto-grants-1997_09
Patent number
US05670456

Reaction notes

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