HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178468988, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 54287317 | HCID 54287317 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 178468988 | HCID 178468988 | — |
Reaction Steps
An excess of diazomethane in diethylether at 0° is added to 3.91 g of 2-ethynylnicotinic acid ethyl ester and the solution allowed to warm to RT and let stand overnight. Acetic acid is added until no further gas evolves and the mixture is extracted with brine, dried over MgSO4, filtered and the solvent removed by evaporation under vacuum to yield the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05670456 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-b92c0db43274409cbec8ca79e141fce4 |
| Source note | uspto-grants-1997_09 |