HCID 19083171, compound → HCID 19083148, compound

HRID 1378922Notes

Reaction equation

HRID 1378922 reaction equation
C([NH:5][S:6]([C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][C:16]=2[F:18])[N:11]([CH3:19])[N:10]=1)(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH3:19][N:11]1[C:12]2[C:17](=[C:16]([F:18])[CH:15]=[CH:14][CH:13]=2)[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[N:10]1

Participants

3

Reactant 1

HCID 19083171HCID 19083171, compound

Product 1

HCID 19083148HCID 19083148, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent2×

Procedure

15 g (53 mmol) of 3-(N-t-butylsulfamoyl)-1-methyl-4-fluoro-1H-indazole was added to 50 ml of trifluoroacetic acid, and the mixture was stirred overnight. After completion of the reaction, trifluoroacetic acid was distilled off under reduced pressure, and the residue was washed with n-hexane to obtain 10.5 g (yield: 86.8%) of 1-methyl-4-fluoro-1H-indazole-3-sulfonamide (slightly purple crystals). Melting point: 221°-223° C.

Workup

  1. distillationwas distilled off under reduced pressure
  2. washthe residue was washed with n-hexane

Sources & evidence

ORD record
ord-0f55a20a11194ba4b95de88025a4e44e
Source dataset
uspto-grants-1997_09
Patent number
US05670452

Reaction notes

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