Hydrochloric Acid → HCID 135829371, compound

HRID 1378929Notes

Reaction equation

HRID 1378929 reaction equation
C1(C[O:5][C:6]2[C:7]3[C:11]([CH:12]=[CH:13][CH:14]=2)=[N:10][N:9]([CH3:15])[C:8]=3[S:16]([NH2:19])(=[O:18])=[O:17])CC1.Cl>C(O)(=O)C>[OH:5][C:6]1[C:7]2[C:11]([CH:12]=[CH:13][CH:14]=1)=[N:10][N:9]([CH3:15])[C:8]=2[S:16]([NH2:19])(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19083157HCID 19083157, compound

Product 1

HCID 135829371HCID 135829371, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture comprising 62 g (221 mmol) of 4-cyclopropylmethoxy-2-methyl-2H-indazole-3-sulfonamide, 120 ml of acetic acid and 120 ml of concentrated hydrochloric acid, was stirred at 80° C. for one hour. After concentrating acetic acid.hydrochloric acid, the mixture was poured into ice water. Crystals were collected by filtration and washed with water. Further, the crystals were washed with IPE and dried to obtain 35.1 g (yield: 70%) of the desired product. Melting point: 180°-181° C.

Workup

  1. concentrationAfter concentrating acetic acid
  2. additionhydrochloric acid, the mixture was poured into ice water
  3. filtrationCrystals were collected by filtration
  4. washwashed with water
  5. washFurther, the crystals were washed with IPE
  6. customdried

Sources & evidence

ORD record
ord-4dd86f73a12b495485b23d04147e256b
Source dataset
uspto-grants-1997_09
Patent number
US05670452

Reaction notes

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