Hydrochloric Acid → HCID 19083159, compound

HRID 1378934Notes

Reaction equation

HRID 1378934 reaction equation
CN(C)C=[N:4][S:5]([C:8]1[N:9]([CH3:21])[N:10]=[C:11]2[C:16]=1[C:15]([O:17][CH2:18][CH2:19][F:20])=[CH:14][CH:13]=[CH:12]2)(=[O:7])=[O:6].Cl>C(O)C>[F:20][CH2:19][CH2:18][O:17][C:15]1[C:16]2[C:11]([CH:12]=[CH:13][CH:14]=1)=[N:10][N:9]([CH3:21])[C:8]=2[S:5]([NH2:4])(=[O:6])=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86749619N1,N1-dimethyl-N2-([4-(2-fluoroethoxy)-2-methyl-2H-indazol-3-yl]sulfonyl}formamidine

Product 1

HCID 19083159HCID 19083159, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture comprising 3.4 g of N1,N1 -dimethyl-N2 -{[4-(2-fluoroethoxy)-2-methyl-2H-indazol-3-yl]sulfonyl}formamidine, 5 ml of concentrated hydrochloric acid and 50 ml of ethanol, was refluxed for 12 hours. Disappearance of the starting material was confirmed by TLC, and then ethanol was distilled off. Water was added to the residue, whereupon the formed crystals were collected by filtration and washed with water and IPE to obtain 2.4 g (yield: 85%) of the desired product. Melting point: 178°-180° C.

Workup

  1. temperaturewas refluxed for 12 hours
  2. distillationethanol was distilled off
  3. additionWater was added to the residue, whereupon the formed crystals
  4. filtrationwere collected by filtration
  5. washwashed with water and IPE

Sources & evidence

ORD record
ord-ef0aba797360410bae35aa3fe2b6524c
Source dataset
uspto-grants-1997_09
Patent number
US05670452

Reaction notes

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