Piperidine → HCID 22908993, compound

HRID 1378980Notes

Reaction equation

HRID 1378980 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:31]([OH:34])(=[O:33])=O)[C:6](=[CH:27][C:28]=1[O:29][CH3:30])/[CH:7]=[CH:8]/[C:9]1[N:17]([CH3:18])[C:16]2[C:15](=[O:19])[N:14]([CH2:20][CH2:21][CH3:22])[C:13](=[O:23])[N:12]([CH2:24][CH2:25][CH3:26])[C:11]=2[N:10]=1.[NH:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1>>[CH3:1][O:2][C:3]1[C:28]([O:29][CH3:30])=[CH:27][C:6](/[CH:7]=[CH:8]/[C:9]2[N:17]([CH3:18])[C:16]3[C:15](=[O:19])[N:14]([CH2:20][CH2:21][CH3:22])[C:13](=[O:23])[N:12]([CH2:24][CH2:25][CH3:26])[C:11]=3[N:10]=2)=[C:5]([S:31]([N:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)(=[O:34])=[O:33])[CH:4]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 22909004HCID 22909004, compound

Product 1

HCID 22908993HCID 22908993, compoundYield 55%

Procedure

Substantially the same procedure as in Example 2 was repeated using 1.00 g (1.96 mmol) of Compound 1 obtained in Example 1 and 1.93 ml (19.6 mmol) of piperidine. The resulting crude crystals were recrystallized from dimethylsulfoxide/water to give 600 mg (yield 55%) of Compound 4 as a pale yellow powder.

Workup

  1. customThe resulting crude crystals were recrystallized from dimethylsulfoxide/water

Sources & evidence

ORD record
ord-a248ed4c280b404e9efbed11faca6876
Source dataset
uspto-grants-1997_09
Patent number
US05670498

Reaction notes

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