Ammonia → HCID 22908992, compound

HRID 1378982Notes

Reaction equation

HRID 1378982 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:31]([OH:34])(=O)=[O:32])[C:6](=[CH:27][C:28]=1[O:29][CH3:30])/[CH:7]=[CH:8]/[C:9]1[N:17]([CH3:18])[C:16]2[C:15](=[O:19])[N:14]([CH2:20][CH2:21][CH3:22])[C:13](=[O:23])[N:12]([CH2:24][CH2:25][CH3:26])[C:11]=2[N:10]=1.[NH3:35]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:31]([NH2:35])(=[O:34])=[O:32])[C:6](=[CH:27][C:28]=1[O:29][CH3:30])/[CH:7]=[CH:8]/[C:9]1[N:17]([CH3:18])[C:16]2[C:15](=[O:19])[N:14]([CH2:20][CH2:21][CH3:22])[C:13](=[O:23])[N:12]([CH2:24][CH2:25][CH3:26])[C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22909004HCID 22909004, compound

Product 1

HCID 22908992HCID 22908992, compoundYield 70%

Procedure

Substantially the same procedure as in Example 2 was repeated using 1.00 g (1.96 mmol) of Compound 1 obtained in Example 1 and 0.6 ml of conc. aqueous ammonia. The resulting crude crystals were recrystallized from dioxane/water to give 670 mg (yield 70%) of Compound 9 as yellow needles.

Workup

  1. customThe resulting crude crystals were recrystallized from dioxane/water

Sources & evidence

ORD record
ord-11a5daa9c6d34689bafbd12af22c6c18
Source dataset
uspto-grants-1997_09
Patent number
US05670498

Reaction notes

Loading…