Glycolic Acid → HCID 22908988, compound

HRID 1378993Notes

Reaction equation

HRID 1378993 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[C:15](O)(=O)[CH2:16][OH:17]>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:15]([CH2:16][OH:17])=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

Participants

3

Reactant 2

HCID 757Glycolic AcidHCID 45721335,6-Diamino-1,3-diethyluracil

Product 1

HCID 22908988HCID 22908988, compoundYield 60%

Procedure

Substantially the same procedure as in Reference Example 1 was repeated using 5.0 g (25.2 mmol) of 5,6-diamino-1,3-diethyluracil [J. Am. Chem. Soc., 75, 114 (1953)] and 8.4 g (111 mmol) of glycolic acid. The resulting crude crystals were recrystallized from methanol to give 3.56 g (yield 60%) of Compound d as white needles.

Workup

  1. customThe resulting crude crystals were recrystallized from methanol

Sources & evidence

ORD record
ord-0b1324504931452484e945542e2bac5f
Source dataset
uspto-grants-1997_09
Patent number
US05670498

Reaction notes

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