反应详情

A mixture of 3-dimethylamino-1-(4-fluorophenyl)-2-(pyridin-4-yl)-2-propen-1-one (6.15 g) and hydroxylamine hydrochloride (4.75 g) in dry ethanol (40 ml) was refluxed for 20 minutes. The mixture was cooled and concentrated in vacuo. The residue was dissolved in dilute hydrochloric acid and then treated with an aqueous saturated sodium bicarbonate solution. The precipitates were collected by filtration, washed with water, and dried to give 5-(4-fluorophenyl)-4-(pyridin-4-yl)isoxazole (5.35 g).

1. temperaturewas refluxed for 20 minutes
2. temperatureThe mixture was cooled
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in dilute hydrochloric acid
5. additiontreated with an aqueous saturated sodium bicarbonate solution
6. filtrationThe precipitates were collected by filtration
7. washwashed with water
8. customdried