HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naphthalimide → HCID 131720205, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naphthalimide | HCID 66491 | — |
| Reactant | N-(2-Chloroethyl)-1,8-naphthalimide | HCID 522559 | — |
| Reactant | 4-Chloro-piperidine-1-carboxylic acid tert-butyl ester | HCID 11138624 | — |
| Reactant | 5-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11769929 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 131720205 | HCID 131720205 | — |
Reaction Steps
1.2 g of 2-(2-chloroethyl)-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione ("A") [obtainable by reaction of 2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione with 1,2-dichloroethane to give 2-(2-chloroethyl)-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione] and 1.0 g of 4-(5-fluoroindol-3-yl)piperidine [obtainable by reaction of N-BOC-4-chloropiperidine with 5-fluoroindole and subsequent removal of the protective group] are dissolved in 200 ml of acetonitrile and the mixture is stirred at room temperature for 8 hours. Customary working up gives 2-[2-(4-(5-fluoro-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione, tetrahydrate, m.p. 235°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05670511 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-0d896ffe3af942e9aaae1ec8e18598c8 |
| Source note | uspto-grants-1997_09 |