HRID13791

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCN(Cc2ccc(C(=O)O)cc2C(F)(F)F)CC1

HCID23145899

未命名化合物

HCID23145966

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(CN3CCN(C(=O)OC(C)(C)C)CC3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cncc(Br)c2)n1

HCID23145942

未命名化合物

PROCEDURE

实验过程

This compound was prepared in the same manner as in Example 34, except that 4-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethylbenzoic acid (Reference Example 13) and 3-[4-(5-bromopyridin-3-yl)pyrimidin-2-ylamino]-4-methylaniline (Reference Example 19) were used.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d63c0a04b7714bd48997ed15ef4025f9
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07728131B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][C:16]=2[C:24]([F:27])([F:26])[F:25])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:28][C:29]1[CH:30]=[C:31]([C:35]2[CH:40]=[CH:39][N:38]=[C:37]([NH:41][C:42]3[CH:43]=[C:44]([CH:46]=[CH:47][C:48]=3[CH3:49])[NH2:45])[N:36]=2)[CH:32]=[N:33][CH:34]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([NH:45][C:44]3[CH:46]=[CH:47][C:48]([CH3:49])=[C:42]([NH:41][C:37]4[N:36]=[C:35]([C:31]5[CH:32]=[N:33][CH:34]=[C:29]([Br:28])[CH:30]=5)[CH:40]=[CH:39][N:38]=4)[CH:43]=3)=[O:21])=[CH:17][C:16]=2[C:24]([F:26])([F:25])[F:27])[CH2:10][CH2:9]1)=[O:7])([CH3:3])([CH3:2])[CH3:4]