4-[4-(t-Butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethylbenzoic acid → 4-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethyl-N-{3-[4-(5-bromopyridin-3-yl)pyrimidin-2-ylamino]-4-methylphenyl}benzamide

HRID 13791Notes

Reaction equation

HRID 13791 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][C:16]=2[C:24]([F:27])([F:26])[F:25])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:28][C:29]1[CH:30]=[C:31]([C:35]2[CH:40]=[CH:39][N:38]=[C:37]([NH:41][C:42]3[CH:43]=[C:44]([CH:46]=[CH:47][C:48]=3[CH3:49])[NH2:45])[N:36]=2)[CH:32]=[N:33][CH:34]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([NH:45][C:44]3[CH:46]=[CH:47][C:48]([CH3:49])=[C:42]([NH:41][C:37]4[N:36]=[C:35]([C:31]5[CH:32]=[N:33][CH:34]=[C:29]([Br:28])[CH:30]=5)[CH:40]=[CH:39][N:38]=4)[CH:43]=3)=[O:21])=[CH:17][C:16]=2[C:24]([F:26])([F:25])[F:27])[CH2:10][CH2:9]1)=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

3

Reactant 2

HCID 231458994-[4-(t-Butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethylbenzoic acidHCID 231459663-[4-(5-Bromopyridin-3-yl)pyrimidin-2-ylamino]-4-methylaniline

Product 1

HCID 231459424-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethyl-N-{3-[4-(5-bromopyridin-3-yl)pyrimidin-2-ylamino]-4-methylphenyl}benzamide

Procedure

This compound was prepared in the same manner as in Example 34, except that 4-[4-(t-butoxycarbonyl)piperazin-1-ylmethyl]-3-trifluoromethylbenzoic acid (Reference Example 13) and 3-[4-(5-bromopyridin-3-yl)pyrimidin-2-ylamino]-4-methylaniline (Reference Example 19) were used.

Sources & evidence

ORD record
ord-d63c0a04b7714bd48997ed15ef4025f9
Source dataset
uspto-grants-2010_06
Patent number
US07728131B2

Reaction notes

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