Hydrochloric Acid → HCID 22909698, compound

HRID 1379107Notes

Reaction equation

HRID 1379107 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:25](OCC)=[O:26])=[N:11]2)=[CH:6][CH:5]=1)([OH:3])=[O:2].C[O-].[Na+].Cl.C([NH2:36])=O>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:22])=[O:23])=[CH:17][CH:16]=3)=[CH:13][C:12]([C:25]([NH2:36])=[O:26])=[N:11]2)=[CH:8][CH:9]=1)([OH:3])=[O:2]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 713FormamideHCID 10942334Sodium MethoxideHCID 22909684HCID 22909684, compound

Product 1

HCID 22909698HCID 22909698, compound

Conditions

Temperature
45 °C

Procedure

A mixture of ethyl 1-(4-carboxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylate (3.9 g) and sodium methoxide (3 g) in formamide (40 ml) was stirred at 45° C. for 3 hours. The mixture was poured into a mixture of ice-water and hydrochloric acid. The precipitates were collected, washed with water, and dried to give crystals of 1-(4-carboxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxamide (3.2 g).

Workup

  1. customThe precipitates were collected
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-79dea35f5e6a4aaa8f21de19407806d2
Source dataset
uspto-grants-1997_09
Patent number
US05670533

Reaction notes

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