Hydrochloric Acid → HCID 70196610, compound

Participants

Reaction Steps

A mixture of (2R)-4-(trans-cinnamoyl)-1-[3-formylamino-5-(trifluoromethyl)benzoyl]-2-(1H-indol-3-yl-methyl)piperazine (280 mg) and aqueous 10% hydrochloric acid (1 ml) in methanol (10 ml) was stirred at room temperature for 6 hours. The mixture was evaporated under reduced pressure. The resulting powder was collected by filtration and dried to give (2R)-1-[3-amino-5-(trifluoromethyl)benzoyl]-4-(trans-cinnamoyl)-2-(1H-indol-3-yl-methyl)piperazine hydrochloride (280 mg).

Provenance & Evidence