Hydrochloric Acid → HCID 70196610, compound

HRID 1379213Notes

Reaction equation

HRID 1379213 reaction equation
[C:1]([N:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:31])[C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([NH:28]C=O)[CH:19]=2)[C@H:13]([CH2:32][C:33]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[NH:35][CH:34]=2)[CH2:12]1)(=[O:10])/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:42]>CO>[ClH:42].[NH2:28][C:20]1[CH:19]=[C:18]([CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=1)[C:17]([N:14]1[CH2:15][CH2:16][N:11]([C:1](=[O:10])/[CH:2]=[CH:3]/[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:12][C@H:13]1[CH2:32][C:33]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:35][CH:34]=1)=[O:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86751326HCID 86751326, compound

Product 1

HCID 70196610HCID 70196610, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (2R)-4-(trans-cinnamoyl)-1-[3-formylamino-5-(trifluoromethyl)benzoyl]-2-(1H-indol-3-yl-methyl)piperazine (280 mg) and aqueous 10% hydrochloric acid (1 ml) in methanol (10 ml) was stirred at room temperature for 6 hours. The mixture was evaporated under reduced pressure. The resulting powder was collected by filtration and dried to give (2R)-1-[3-amino-5-(trifluoromethyl)benzoyl]-4-(trans-cinnamoyl)-2-(1H-indol-3-yl-methyl)piperazine hydrochloride (280 mg).

Workup

  1. customThe mixture was evaporated under reduced pressure
  2. filtrationThe resulting powder was collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-91ff855a279b4e88ab65c4ecd6e53197
Source dataset
uspto-grants-1997_09
Patent number
US05670505

Reaction notes

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