反应详情

温度

45 °C

A solution of 70.0 g of a 92:8 mixture of the (4S,5S)- and (4S,5R)-isomers of methyl 4-benzyl-2-oxo-oxazolidine-5-carboxylate and 7.0 g of potassium tert.butylate in 700 ml of THF was stirred at 20° C. for four hours and at 45° C. for 2 hours, the solution was washed twice with semi-saturated sodium chloride solution, dried over MgSO4, filtered and the filtrate was evaporated to give 68 g (97%) of 95% methyl (4S,5R)-4-benzyl-2-oxo-oxazolidine-5-carboxylate (tlc (SiO2, ethyl acetate):Rf =0.5).

1. washthe solution was washed twice with semi-saturated sodium chloride solution
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. customthe filtrate was evaporated