Methyl iodide → HCID 22910410, compound

HRID 1379297Notes

Reaction equation

HRID 1379297 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([O:11][CH:12]([CH3:14])[CH3:13])(=[O:10])=[O:9].F[C:16]1C=CC=CC=1S(Cl)(=O)=O.C([Li])CCC.IC.FC1C=CC=C(C)C=1S(OC(C)C)(=O)=O>>[F:1][C:2]1[C:7]([CH3:16])=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([O:11][CH:12]([CH3:14])[CH3:13])(=[O:9])=[O:10]

Participants

6

Reactant 5

HCID 6328Methyl iodideHCID 1377612-Fluorobenzenesulphonyl chlorideHCID 22910444HCID 22910444, compoundHCID 22910486HCID 22910486, compoundHCID 178418339Butyllithium

Product 1

HCID 22910410HCID 22910410, compound

Procedure

Isopropyl 2-fluorobenzenesulfonate was made from 2-fluorobenzenesulfonyl chloride and treated first with butyl lithium and then with iodomethane in a manner analogous to that set forth above in Example to yield isopropyl 2-fluoro-6-methylbenzenesulfonate (formed as a 2:1 mixture with isopropyl 2-fluoro-3-methylbenzenesulfonate as the minor isomer).

Sources & evidence

ORD record
ord-41bcc24fbd304cea9ca3aa55c94c5396
Source dataset
uspto-grants-1997_09
Patent number
US05670691

Reaction notes

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