Oxalyl chloride → HCID 22910224, compound

HRID 1379352Notes

Reaction equation

HRID 1379352 reaction equation
[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](=[O:20])[C:7]([F:19])([F:18])[CH:8]([OH:17])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)(=O)C(Cl)=O>CS(C)=O>[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](=[O:20])[C:7]([F:18])([F:19])[C:8](=[O:17])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 22910065HCID 22910065, compound

Product 1

HCID 22910224HCID 22910224, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

According to the procedure of Thaisrivongs et. al. (J. Med. Chem., 1986, 29, 2080), the resultant compound of Example 46 was treated with dimethylsulfoxide and oxalyl chloride to give the desired compound.

Sources & evidence

ORD record
ord-53080b31588f446e93c3f8256c44083f
Source dataset
uspto-grants-1997_09
Patent number
US05670675

Reaction notes

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