Methyl iodide → HCID 22872083, compound

HRID 1379477Notes

Reaction equation

[CH3:1][C@@:2]12[C:11]3[CH:12]=[CH:13][C:14]([S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)(=[O:18])=[O:17])=[CH:15][C:10]=3[CH2:9][CH2:8][C@H:7]1[NH:6][C:5](=[O:25])[CH2:4][CH2:3]2.[CH3:26]I>>[CH3:26][N:6]1[C@H:7]2[C@@:2]([CH3:1])([C:11]3[CH:12]=[CH:13][C:14]([S:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)(=[O:18])=[O:17])=[CH:15][C:10]=3[CH2:9][CH2:8]2)[CH2:3][CH2:4][C:5]1=[O:25]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 53993388HCID 53993388, compound

Product 1

HCID 22872083HCID 22872083, compound

Procedure

A 200 mg portion of (4aR)-(10bR)-10b-methyl-8-(phenylsulfonyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]-quinolin-3-one was methylated with methyl iodide to obtain 144 mg of the desired product. mp 165°-167° FDMS: m/e=369. α[D]589 =+76.2, α[D]365 =+269.7 (chloroform).

Sources & evidence

ORD record: ord-d2c3cfcc06d2451ab9f3fd7ae8c7de60
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05670514

Reaction notes

Loading…