反应详情

1-Methyl-1-(3,5-dichlorophenyl)ethylamine (7.5 g) was gradually added to formalin (37% aqueous HCHO solution) (4.6 g) at room temperature. This mixture was subjected as it is to reaction for 7 hours. A saturated sodium bicarbonate solution was added to the reaction mixture, the resultant was extracted with ether and this organic layer was washed with saturated saline solution, and then dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure to obtain 8.6 g of N-methylene-1-methyl-1-(3,5-dichloro-phenyl)ethylamine as white crystals.

1. customis to reaction for 7 hours
2. extractionthe resultant was extracted with ether
3. washthis organic layer was washed with saturated saline solution
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed by evaporation under reduced pressure