Isovaleryl chloride → HCID 22877220, compound

HRID 1379593Notes

Reaction equation

[CH3:1][CH:2]([C@H:4]([CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:5](Cl)=[O:6])[CH3:3].CC(C)CC(Cl)=[O:19]>>[CH3:1][CH:2]([C@H:4]([CH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:5]([OH:19])=[O:6])[CH3:3]

Participants

Reactant 2

HCID 66054Isovaleryl chloride

HCID 54045815HCID 54045815, compound

Product 1

HCID 22877220HCID 22877220, compound

Procedure

α(S)-(1-Methylethyl)cyclohexanepropionic acid chloride: By following procedure (a) of this example but replacing propionyl chloride with 3-methylbutanoyl chloride, α(S)-(1-methylethyl)-cyclohexane propionic acid is obtained. 1H NMR (CDCl3) δ 2.27 (ddd, J=10.5, 7, 3.5 Hz, 1H), 1.91-1.80 (m, 2H), 1.73-1.55 (m, 5H), 1.35-1.08 (m, 5H), 0.98-0.77 (m, 2H), 0.97 (d, J=7 Hz, 3H), 0.96 (d, J=7 Hz, 3H). Thereafter, the latter compound was converted to its corresponding acid chloride in the same manner as described in section (a) of this example.

Sources & evidence

ORD record: ord-125cc07ab0ad4bf6962eb89615b6d145
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05672586

Reaction notes

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