Isovaleryl chloride → HCID 22877220, compound

Participants

Reaction Steps

α(S)-(1-Methylethyl)cyclohexanepropionic acid chloride: By following procedure (a) of this example but replacing propionyl chloride with 3-methylbutanoyl chloride, α(S)-(1-methylethyl)-cyclohexane propionic acid is obtained. 1H NMR (CDCl3) δ 2.27 (ddd, J=10.5, 7, 3.5 Hz, 1H), 1.91-1.80 (m, 2H), 1.73-1.55 (m, 5H), 1.35-1.08 (m, 5H), 0.98-0.77 (m, 2H), 0.97 (d, J=7 Hz, 3H), 0.96 (d, J=7 Hz, 3H). Thereafter, the latter compound was converted to its corresponding acid chloride in the same manner as described in section (a) of this example.

Provenance & Evidence