Hydrogen Peroxide → HCID 67800504, compound

HRID 1379609Notes

Reaction equation

HRID 1379609 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:31]=[CH:32][CH:33]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[O:30])[CH2:17][S:18][CH2:19][CH2:20][N:21]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[C:22]([CH3:24])=[O:23])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:34]O>C(O)(=O)C>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:31]=[CH:32][CH:33]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16](=[O:30])[CH2:17][S:18]([CH2:19][CH2:20][N:21]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)[C:22]([CH3:24])=[O:23])=[O:34])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 67799968HCID 67799968, compound

Product 1

HCID 67800504HCID 67800504, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

There was dissolved 1.0 g (0.002 mol) of N-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-[2-(2-thienylacetamino)ethylthio]acetamide in 30 ml, of acetic acid and added 0.24 ml, (0.0022 mol) of 30% aqueous solution of hydrogen peroxide under cooling with ice, and the mixture was stirred for 12 hours at room temperature. The solvent was removed under reduced pressure, and then the residue was purified by silica gel column chromatography (chloroform:ethanol=5:1) to give 0.72 g of the titled compound as crystals.

Workup

  1. temperatureunder cooling with ice
  2. customThe solvent was removed under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (chloroform:ethanol=5:1)

Sources & evidence

ORD record
ord-70ef14fef9a2455e88ccd08a45b00a1a
Source dataset
uspto-grants-1997_09
Patent number
US05672597

Reaction notes

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