HRID1379762

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C(Cl)(c2ccccc2)c2ccc(OC)cc2)cc1

HCID96831

1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)

C21H19ClO2

结构：CC(C)C(=O)[C@]1(n2cnc3c(=O)[nH]c(N)nc32)C[C@H](O)[C@@H](CO)O1.N#N

HCID136395926

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(OC[C@H]2O[C@@](C(=O)C(C)C)(n3cnc4c(=O)[nH]c(N)nc43)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1.N#N

HCID136395924

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

溶剂HCID1049

Pyridine

C5H5N

2 次

PROCEDURE

实验过程

The tritylation procedure of Jones45 was modified such that no DMAP was used. To 3.37 g (10.0 mmol) of N2 -isobutyryl-2'-deoxyguanosine (that was first concentrated from dry pyridine) in 50 mL of dry pyridine, was added 4.06 g (12.0 mmol, 1.20 equiv.) of 4,4'-dimethoxytrityl chloride. The reaction was stirred for 15 h, and then concentrated. The residue was partitioned between CH2Cl2 and 0.5% aq. NaHCO3, shaken, and separated. The organic layer was washed with 0.5% aq. NaHCO3 and dried. The crude product was purified by flash chromatography.

WORKUP

后处理

concentrationconcentrated
customThe residue was partitioned between CH2Cl2 and 0.5% aq. NaHCO3
stirringshaken
customseparated
washThe organic layer was washed with 0.5% aq. NaHCO3
customdried
customThe crude product was purified by flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-17e30a977b3048eea8c1eb5609395ca2
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05672697
来源说明: uspto-grants-1997_09

反应 SMILES

[N:1]#[N:2].[C:3]([C@@:8]1([N:16]2[C:26]3[N:25]=[C:23]([NH2:24])[NH:22][C:20](=[O:21])[C:19]=3[N:18]=[CH:17]2)[O:15][C@H:12]([CH2:13][OH:14])[C@@H:10]([OH:11])[CH2:9]1)(=[O:7])[CH:4]([CH3:6])[CH3:5].[CH3:27][O:28][C:29]1[CH:50]=[CH:49][C:32]([C:33](Cl)([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)=[CH:31][CH:30]=1>CN(C1C=CN=CC=1)C.N1C=CC=CC=1>[N:1]#[N:2].[C:3]([C@@:8]1([N:16]2[C:26]3[N:25]=[C:23]([NH2:24])[NH:22][C:20](=[O:21])[C:19]=3[N:18]=[CH:17]2)[O:15][C@H:12]([CH2:13][O:14][C:33]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)([C:34]2[CH:39]=[CH:38][C:37]([O:40][CH3:41])=[CH:36][CH:35]=2)[C:32]2[CH:31]=[CH:30][C:29]([O:28][CH3:27])=[CH:50][CH:49]=2)[C@@H:10]([OH:11])[CH2:9]1)(=[O:7])[CH:4]([CH3:6])[CH3:5]