5'-O-(4,4'-Dimethoxytrityl)thymidine → 3'-O-(t-butyldimethylsilyl)thymidine

HRID 1379770Notes

Reaction equation

HRID 1379770 reaction equation
COC1C=CC(C([O:22][CH2:23][C@H:24]2[O:28][C@@H:27]([N:29]3[CH:37]=[C:35]([CH3:36])[C:33](=[O:34])[NH:32][C:30]3=[O:31])[CH2:26][C@@H:25]2[OH:38])(C2C=CC=CC=2)C2C=CC(OC)=CC=2)=CC=1.[Si:41](O[C@@H]1[C@@H](CO)O[C@@H](N2C3N=C(NC(=O)C(C)C)NC(=O)C=3N=C2)C1)([C:44]([CH3:47])([CH3:46])[CH3:45])([CH3:43])[CH3:42]>>[Si:41]([O:38][C@@H:25]1[C@@H:24]([CH2:23][OH:22])[O:28][C@@H:27]([N:29]2[CH:37]=[C:35]([CH3:36])[C:33](=[O:34])[NH:32][C:30]2=[O:31])[CH2:26]1)([C:44]([CH3:47])([CH3:46])[CH3:45])([CH3:43])[CH3:42]

Participants

3

Reactant 2

HCID 1624195'-O-(4,4'-Dimethoxytrityl)thymidineHCID 136483518N-(9-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-3H-purin-2-yl)isobutyramide

Product 1

HCID 4538443'-O-(t-butyldimethylsilyl)thymidine

Procedure

This compound was prepared from 5'-O-(4,4'-dimethoxytrityl)-thymidine by the same procedure used for the preparation of 3'-O-t-butyldimethylsilyl-N2 -isobutyryl-2'-deoxyguanosine.

Sources & evidence

ORD record
ord-ba677e714eaf4c4b96abe6ba5d83e478
Source dataset
uspto-grants-1997_09
Patent number
US05672697

Reaction notes

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