HRID1379772

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C(OC[C@H]2O[C@@](C(=O)C(C)C)(n3cnc4c(=O)[nH]c(N)nc43)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1.N#N

HCID136395924

未命名化合物

结构：CC(C)C(=O)Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2F)c(=O)[nH]1

HCID136395929

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(=O)[nH]c(NC(=O)C(C)C)nc43)[C@@H](F)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

HCID136395928

未命名化合物

PROCEDURE

实验过程

This compound is prepared from 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-N2 -isobutyrylguanine by the same procedure used for the preparation of N2 -isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b6f70c1e54114e6e8ae9a7fd2f58e1fb
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05672697
来源说明: uspto-grants-1997_09

反应 SMILES

[F:1][C@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][OH:9])[O:4][C@H:3]1[N:10]1[CH:18]=[N:17][C:16]2[C:15](=[O:19])[NH:14][C:13]([NH:20][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])=[N:12][C:11]1=2.N#N.C([C@@]1(N2C3N=C(N)NC(=O)C=3N=C2)O[C@H](CO[C:40]([C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)([C:49]2[CH:54]=[CH:53][C:52]([O:55][CH3:56])=[CH:51][CH:50]=2)[C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][CH:42]=2)[C@@H](O)C1)(=O)C(C)C>>[CH3:56][O:55][C:52]1[CH:51]=[CH:50][C:49]([C:40]([O:9][CH2:8][C@H:5]2[O:4][C@@H:3]([N:10]3[CH:18]=[N:17][C:16]4[C:15](=[O:19])[NH:14][C:13]([NH:20][C:21](=[O:25])[CH:22]([CH3:23])[CH3:24])=[N:12][C:11]3=4)[C@@H:2]([F:1])[C@@H:6]2[OH:7])([C:57]2[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=2)[C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[CH:43][CH:42]=2)=[CH:54][CH:53]=1