HRID1379777

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)O[C@H]1C[C@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)O[C@@H]1CO

HCID11590906

N-[9-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]benzamide

C23H31N5O4Si

结构：COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@@H](F)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

HCID67563215

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)O[C@H]1[C@H](F)[C@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)O[C@@H]1CO

HCID54410811

未命名化合物

PROCEDURE

实验过程

This compound is prepared from 9-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-2-fluoro-β-D-arabinofuranosyl]-N6 -benzoyladenine by the same procedure used for the preparation of 3'-O-t-butyldimethylsilyl-N6 -benzoyl-2'-deoxyadenosine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-26c124c811b8464eabf0d5e3434a8dcd
来源数据集: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05672697
来源说明: uspto-grants-1997_09

反应 SMILES

COC1C=CC(C([O:22][CH2:23][C@H:24]2[O:28][C@@H:27]([N:29]3[CH:37]=[N:36][C:35]4[C:30]3=[N:31][CH:32]=[N:33][C:34]=4[NH:38][C:39](=[O:46])[C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[C@@H:26]([F:47])[C@@H:25]2[OH:48])(C2C=CC=CC=2)C2C=CC(OC)=CC=2)=CC=1.[Si:51](O[C@@H]1[C@@H](CO)O[C@@H](N2C3N=CN=C(NC(=O)C4C=CC=CC=4)C=3N=C2)C1)([C:54]([CH3:57])([CH3:56])[CH3:55])([CH3:53])[CH3:52]>>[Si:51]([O:48][C@@H:25]1[C@@H:24]([CH2:23][OH:22])[O:28][C@@H:27]([N:29]2[CH:37]=[N:36][C:35]3[C:30]2=[N:31][CH:32]=[N:33][C:34]=3[NH:38][C:39](=[O:46])[C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[C@H:26]1[F:47])([C:54]([CH3:57])([CH3:56])[CH3:55])([CH3:53])[CH3:52]