HRID13798

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：Cc1ccc(NC(=O)c2ccc(CBr)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1

HCID23145971

未命名化合物

HCID68693400

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccc(CN3CC[C@H](CN(C)C)C3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1

HCID11192594

未命名化合物

PROCEDURE

实验过程

This compound was prepared in the same manner as in Example 47, except that 4-(bromomethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]phenyl}benzamide (Reference Example 82) and (S)-3-(dimethylaminomethyl)pyrrolidine dihydrochloride (Reference Example 35) were used, and that potassium carbonate was used in an amount of 5 equivalents based on a raw material.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1391590f76f44027b0785eb5a37067dc
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07728131B2
来源说明: uspto-grants-2010_06

反应 SMILES

Br[CH2:2][C:3]1[CH:31]=[CH:30][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([NH:17][C:18]3[N:23]=[C:22]([C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)[CH:21]=[CH:20][N:19]=3)[CH:11]=2)=[O:8])=[CH:5][C:4]=1[C:32]([F:35])([F:34])[F:33].Cl.Cl.[CH3:38][N:39]([CH2:41][C@H:42]1[CH2:46][CH2:45][NH:44][CH2:43]1)[CH3:40].C(=O)([O-])[O-].[K+].[K+]>>[CH3:38][N:39]([CH2:41][C@H:42]1[CH2:46][CH2:45][N:44]([CH2:2][C:3]2[CH:31]=[CH:30][C:6]([C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([NH:17][C:18]4[N:23]=[C:22]([C:24]5[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=5)[CH:21]=[CH:20][N:19]=4)[CH:11]=3)=[O:8])=[CH:5][C:4]=2[C:32]([F:35])([F:34])[F:33])[CH2:43]1)[CH3:40]