Potassium Carbonate → HCID 11192594, compound

HRID 13798Notes

Reaction equation

HRID 13798 reaction equation
Br[CH2:2][C:3]1[CH:31]=[CH:30][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([NH:17][C:18]3[N:23]=[C:22]([C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)[CH:21]=[CH:20][N:19]=3)[CH:11]=2)=[O:8])=[CH:5][C:4]=1[C:32]([F:35])([F:34])[F:33].Cl.Cl.[CH3:38][N:39]([CH2:41][C@H:42]1[CH2:46][CH2:45][NH:44][CH2:43]1)[CH3:40].C(=O)([O-])[O-].[K+].[K+]>>[CH3:38][N:39]([CH2:41][C@H:42]1[CH2:46][CH2:45][N:44]([CH2:2][C:3]2[CH:31]=[CH:30][C:6]([C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([NH:17][C:18]4[N:23]=[C:22]([C:24]5[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=5)[CH:21]=[CH:20][N:19]=4)[CH:11]=3)=[O:8])=[CH:5][C:4]=2[C:32]([F:35])([F:34])[F:33])[CH2:43]1)[CH3:40]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 23145971HCID 23145971, compoundHCID 68693400HCID 68693400, compound

Product 1

HCID 11192594HCID 11192594, compound

Procedure

This compound was prepared in the same manner as in Example 47, except that 4-(bromomethyl)-3-trifluoromethyl-N-{4-methyl-3-[4-(3-pyridyl)pyrimidin-2-ylamino]phenyl}benzamide (Reference Example 82) and (S)-3-(dimethylaminomethyl)pyrrolidine dihydrochloride (Reference Example 35) were used, and that potassium carbonate was used in an amount of 5 equivalents based on a raw material.

Sources & evidence

ORD record
ord-1391590f76f44027b0785eb5a37067dc
Source dataset
uspto-grants-2010_06
Patent number
US07728131B2

Reaction notes

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