Bromine → 3'-Bromo-4'-methyl-1,1'-biphenyl-2-carbonitrile

HRID 1379870Notes

Reaction equation

HRID 1379870 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]#[N:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[Br:16]Br>C(Cl)Cl.FC(F)(F)C([O-])=O.[Ag+]>[Br:16][C:7]1[CH:6]=[C:5]([C:8]2[C:9]([C:14]#[N:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:4]=[CH:3][C:2]=1[CH3:1]

Participants

5

Reactant 2

HCID 24408BromineHCID 1455122-Cyano-4'-methylbiphenyl

Product 1

HCID 218403383'-Bromo-4'-methyl-1,1'-biphenyl-2-carbonitrileYield 41%

Reagents, catalysts & solvents 2

HCID 76299Silver trifluoroacetateCatalyst2×HCID 6344DichloromethaneSolvent

Procedure

A solution of 5.2 g (27 mmol) of 4'-methyl-1,1'-biphenyl-2-nitrile (Step B) in 60 mL of methylene chloride at 0° C. was treated with 6.7 g of silver trifluoroacetate (30 mmol). When all the silver trifluoroacetate was dissolved, 1.6 mL of bromine was added dropwise (4.95 g, 31 mmol) with vigorous stirring. After two hours, the reaction mixture was filtered and the solid washed with methylene chloride. The combined organic layers were washed once with dilute (<1 N) aqueous sodium hydroxide and once with brine. The organic layer was removed, dried over magnesium sulfate, filtered and concentrated under vacuum. The residue was purified by preparative high pressure liquid chromatography on silica, eluting with 10% etherexane to give 3 g (41%) of product. 1H NMR (200 MHz, CDCl3): δ 2.46 (s, 3H), 7.2-7.8 (m, 7H).

Workup

  1. filtrationthe reaction mixture was filtered
  2. washthe solid washed with methylene chloride
  3. washThe combined organic layers were washed once
  4. additionwith dilute (<1 N) aqueous sodium hydroxide
  5. customThe organic layer was removed
  6. dry with materialdried over magnesium sulfate
  7. filtrationfiltered
  8. concentrationconcentrated under vacuum
  9. customThe residue was purified by preparative high pressure liquid chromatography on silica
  10. washeluting with 10% etherexane

Sources & evidence

ORD record
ord-4185e0fe494f49f1bad06eb976f70b2d
Source dataset
uspto-grants-1997_09
Patent number
US05672596

Reaction notes

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