Hydroxyamine hydrochloride → 2-(Hydroxyimino)-3,3-dimethylbutanoic acid

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Reaction Steps

163 g (1 mole) 93.5% trimethylpyruvic acid sodium salt and 69.5 g (1 mole) hydroxylamine hydrochloride were dissolved at 40° C. in 450 ml water. The product crystallized out during slow cooling off under agitation. After 1.5 h agitation in an ice bath the crystals were filtered off, washed with 150 ml ice water and at first pre-dried in a vacuum at 60° C. and then post-dried in a vacuum desiccator over phosphorus pentoxide to constant weight. 117.8 g (yield 81%) trimethylpyruvic acid oxime in the form of colorless crystals were obtained.

Provenance & Evidence