反应详情

163 g (1 mole) 93.5% trimethylpyruvic acid sodium salt and 69.5 g (1 mole) hydroxylamine hydrochloride were dissolved at 40° C. in 450 ml water. The product crystallized out during slow cooling off under agitation. After 1.5 h agitation in an ice bath the crystals were filtered off, washed with 150 ml ice water and at first pre-dried in a vacuum at 60° C. and then post-dried in a vacuum desiccator over phosphorus pentoxide to constant weight. 117.8 g (yield 81%) trimethylpyruvic acid oxime in the form of colorless crystals were obtained.

1. customThe product crystallized out
2. temperatureduring slow cooling off under agitation
3. filtrationAfter 1.5 h agitation in an ice bath the crystals were filtered off
4. washwashed with 150 ml ice water
5. customat first pre-dried in a vacuum at 60° C.
6. dry with materialpost-dried in a vacuum desiccator over phosphorus pentoxide to constant weight