4(Fluoromethyl-ethyl)-nitrobenzene → 4(1-Fluoromethyl-ethyl)-aniline
Reaction equation
[F:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)[CH3:4]>CO.[Pd]>[F:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:4]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
10.3 g (0.057 Mol) 4(1-fluoromethyl-ethyl)-nitrobenzene are dissolved in 250 ml absolute CH3OH and hydrogenated at room temperature and atmospheric pressure in the presence of 0.61 g 10% Pd/C.
Sources & evidence
- ORD record
- ord-7ba063574cf745628233321543db1a15
- Source dataset
- uspto-grants-1986_04
- Patent number
- US04579585
Reaction notes
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