Sulfuric Acid → 3-Bromo-4(1-fluoromethyl-ethyl)-nitrobenzene

HRID 1379978Notes

Reaction equation

HRID 1379978 reaction equation
S(=O)(=O)(O)O.[F:6][CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1)[CH3:9].[Br:19]([O-])(=O)=O.[K+]>O>[Br:19][C:11]1[CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=[CH:15][C:10]=1[CH:8]([CH2:7][F:6])[CH3:9]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 131873674(Fluoromethyl-ethyl)-nitrobenzeneHCID 23673461Potassium Bromate

Product 1

HCID 131873723-Bromo-4(1-fluoromethyl-ethyl)-nitrobenzene

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 80 ml of concentrated sulfuric acid, 80 ml of water and 18.3 g (0.1 Mol) of 4(fluoromethyl-ethyl)-nitrobenzene are added portionwise with stirring 18.3 g (0.11 Mol) potassium bromate at such a rate that the temperature does not exceed 35°.

Workup

  1. customdoes not exceed 35°

Sources & evidence

ORD record
ord-64aa0aaee55d45b0a4adb5908f873599
Source dataset
uspto-grants-1986_04
Patent number
US04579585

Reaction notes

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