Formic Acid → N[4(1-fluoromethyl-ethyl)phenyl]-formamide

HRID 1379979Notes

Reaction equation

HRID 1379979 reaction equation
[F:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)[CH3:4].[CH:12](O)=[O:13]>C1(C)C=CC=CC=1>[F:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]=[O:13])=[CH:7][CH:6]=1)[CH3:4]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 131873684(1-Fluoromethyl-ethyl)-aniline

Product 1

HCID 13187377N[4(1-fluoromethyl-ethyl)phenyl]-formamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 20 g (0.13 Mol) of 4(1-fluoromethyl-ethyl)benzeneamine and 6 g (0.13 Mol) of 98% formic acid in 150 ml of dry toluene is boiled under reflux. When 2.5 ml of water have separated in the water trap, an additional 6 g of formic acid are added and refluxing is continued until no more water and formic acid separate.

Workup

  1. temperatureunder reflux
  2. customWhen 2.5 ml of water have separated in the water trap
  3. additionan additional 6 g of formic acid are added
  4. temperaturerefluxing
  5. customseparate

Sources & evidence

ORD record
ord-fd676d0f19d94e62a36ed75b5f9c45ae
Source dataset
uspto-grants-1986_04
Patent number
US04579585

Reaction notes

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