反应详情

A suspension of 4-chloro-2-fluoro-5-isopropoxynitrobenzene (13.5 g) and platinum dioxide (0.4 g) in ethanol (300 ml) was subjected to catalytic reduction with hydrogen at room temperature (ca. 20° C.) under atmospheric pressure, whereby a designated amount of hydrogen was absorbed. The resultant mixture was filtered to remove insoluble materials, and the filtrate was concentrated. The residue was subjected to purification by silica gel chromatography to give 5.6 g of 4-chloro-2-fluoro-5-isopropoxyphenylaniline. nD24.5 1.5360.

1. custom(ca. 20° C.)
2. customwas absorbed
3. filtrationThe resultant mixture was filtered
4. customto remove insoluble materials
5. concentrationthe filtrate was concentrated
6. customThe residue was subjected to purification by silica gel chromatography